Covalently PEGylated carbon nanotubes with stealth character in vivo

被引：129

作者：

Yang, Sheng-Tao ^{[1
]}

Fernando, K. A. Shiral

Liu, Jia-Hui ^{[1
]}

Wang, Jing ^{[1
]}

Sun, Hong-Fang ^{[1
]}

Liu, Yuanfang ^{[1
]}

Chen, Min ^{[2
]}

Huang, Yipu ^{[2
]}

Wang, Xin

Wang, Haifang ^{[1
]}

Sun, Ya-Ping

机构：

[1] Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

[2] Xiamen Univ, Lab Mass Spectrometry, Dept Oceanog, Xiamen 361005, Peoples R China

来源：

SMALL | 2008年 / 4卷 / 07期

关键词：

biocompatible materials; biodistribution; carbon nanotubes; stealth character;

D O I：

10.1002/smll.200700714

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study was conducted to observe the stealth character of PEGylated single-walled carbon nanotubes (PEG-SWCNs) under blood circulation and biodistribution. The skeleton carbon-13 enriched SWNTs were covalently functionalized with diamine-terminated PEG oligomers and the resulting PEG-SWNTs were utilized for in vivo experiments with isotope ratio mass spectrometry. The PEG-SWNTs content in the solution was determined by isotope-MS. The concentrations of PEG-SWNTs in blood were measured by isotope-MS measurements. The low hepatic uptake of nanotubes was observed in the biodistribution. The TEM analysis was utilized to observe the finding of isotope-MS. The liver was digested using HCIO4-H2O2. The amount of PEG conjugation to SWNTs was determined by using NMR and thermogravimetric analysis. Phermacokinetic and biodistribution results show the distinct stealth character of PEG-SWNTs, with measured blood-circulation time.

引用

页码：940 / 944

页数：5

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