Maintenance versus growth: Investigating the costs of immune activation among children in lowland Bolivia

被引：106

作者：

McDade, T. W. ^{[1
,2
]}

Reyes-Garcia, V. ^{[3
,4
,5
]}

Tanner, S. ^{[6
]}

Huanca, T. ^{[7
]}

Leonard, W. R. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA

[2] Northwestern Univ, C2S, Ctr Social Dispar & Hlth, Inst Policy Res, Evanston, IL 60208 USA

[3] Univ Autonoma Barcelona, ICREA, E-08193 Barcelona, Spain

[4] Univ Autonoma Barcelona, Inst Ciencia & Tecnol Ambientals, E-08193 Barcelona, Spain

[5] Brandeis Univ, Heller Sch Social Policy & Management, Sustainable Int Dev Program, Waltham, MA 02454 USA

[6] Univ Georgia, Dept Anthropol, Athens, GA 30606 USA

[7] CBIDSI, San Borja, Beni, Bolivia

来源：

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY | 2008年 / 136卷 / 04期

关键词：

ecological immunology; human growth and development; acute phase response; life history theory; infectious disease; Amazonia;

D O I：

10.1002/ajpa.20831

中图分类号：

Q98 [人类学];

学科分类号：

030303 ;

摘要：

Immune function is a central component of maintenance effort, and it provides critical protection against the potentially life threatening effects of pathogens. However, immune defenses are energetically expensive, and the resources they consume are not available to support other activities related to growth and/or reproduction. In our study we use a life history theory framework to investigate tradeoffs between maintenance effort and growth among children in a remote area of Amazonian Bolivia. Baseline concentrations of C-reactive protein (CRP) were measured in 309 2- to 10-year olds as an indicator of immune activation, and height was measured at baseline and three months later. Elevated CRP at baseline predicts smaller gains in height over the subsequent three months, with the costs to growth particularly high for 2- to 4-year olds and for those with low energy reserves (in the form of body fat) at the time of immunostimulation. These results provide evidence for a significant tradeoff between investment in immunity and growth in humans, and highlight an important physiological mechanism through which maintenance effort may have lasting effects on child growth and development.

引用

页码：478 / 484

页数：7