Studies on protection of oxindoles

被引：21

作者：

Rajeswaran, WG ^{[1
]}

Cohen, LA ^{[1
]}

机构：

[1] NIDDK, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(98)00679-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protection of amide nitrogen of oxindole and methyloxindole using Boc and Z-groups has been described. Sodium carbonate was found to be an effective base for these protections. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：11375 / 11380

页数：6

共 8 条

[1]

CHIEN CS, 1985, CHEM PHARM BULL, V33, P1843

[2] A MILD 2-STEP METHOD FOR THE HYDROLYSIS METHANOLYSIS OF SECONDARY AMIDES AND LACTAMS [J].

FLYNN, DL ;

ZELLE, RE ;

GRIECO, PA .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (14) :2424-2426

[3] A CONVENIENT METHOD FOR THE PREPARATION OF 1-(TERT-BUTYLOXYCARBONYL)PYRROLES [J].

GREHN, L ;

RAGNARSSON, U .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1984, 23 (04) :296-&

[4] VIBRATIONAL FREQUENCY CORRELATIONS IN HETEROCYCLIC MOLECULES .4. INDOXYL DERIVATIVES [J].

HOLT, SJ ;

KELLIE, AE ;

OSULLIVAN, DG ;

SADLER, PW .

JOURNAL OF THE CHEMICAL SOCIETY, 1958, (MAR) :1217-1223

[5] A FACILE PREPARATION OF 2-(2-ARYLETHYL)INDOLES AND 2-(AMINOMETHYL)INDOLES [J].

NAGARATHNAM, D .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1992, 29 (06) :1371-1373

[6]

RAJESWARAN WG, 1992, SYNTHESIS-STUTTGART, P835

[7] A convenient method of protecting oxindoles [J].

Rajeswaran, WG ;

Cohen, LA .

TETRAHEDRON LETTERS, 1997, 38 (45) :7813-7814

[8]

SADANANDAN EV, 1992, SYNTHESIS-STUTTGART, P648

← 1 →