Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

被引：21

作者：

Conway, SJ

Miller, JC

Howson, PA

Clark, BP

Jane, DE ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Dept Pharmacol, Bristol BS8 1TD, Avon, England

[2] Eli Lilly & Co, Windlesham GU20 6PH, Surrey, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(01)00052-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The syntheses of a range of ring and alpha -substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：777 / 780

页数：4

共 23 条

[1]

Arbuzov A.E., 1906, J RUSS PHYS CHEM SOC, V38, P687

[2]

Baumann E., 1886, CHEM BER-RECL, V19, P3218

[3]

About the formation of substituted hydantoine from aldehydes and ketones - Synthesis of hydantoin (II announcement) [J].