MutaProt: a web interface for structural analysis of point mutations

被引:9
作者
Eyal, E [1 ]
Najmanovich, R [1 ]
Sobolev, V [1 ]
Edelman, M [1 ]
机构
[1] Weizmann Inst Sci, Dept Plant Sci, IL-76100 Rehovot, Israel
关键词
D O I
10.1093/bioinformatics/17.4.381
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A web-based tool, termed 'MutaProt', is described which analyses pairs of PDB files whose members differ in one, or two, amino acids. MutaProt examines the micro environment surrounding the exchanged residue(s) and can be searched by specifying a PDB ID, keywords, or any pair of amino acids. Detailed information about accessibility of the exchanged residue(s) and its atomic contacts are provided based on CSU software (Sobolev et al., Bioinformatics, 15, 327-332, 1999). An interactive 3D presentation of the superimposed regions around the mutation(s) is included. MutaProt is updated weekly.
引用
收藏
页码:381 / 382
页数:2
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