Chromosomal passengers and the (aurora) ABCs of mitosis

被引：489

作者：

Adams, RR ^{[1
]}

Carmena, M ^{[1
]}

Earnshaw, WC ^{[1
]}

机构：

[1] Univ Edinburgh, Inst Cell & Mol Biol, Wellcome Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0962-8924(00)01880-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.

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页码：49 / 54

页数：6

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