African origin of modern humans in East Asia: A tale of 12,000 Y chromosomes

被引：125

作者：

Ke, YH

Su, B

Song, XF

Lu, DR

Chen, LF

Li, HY

Qi, CJ

Marzuki, S

Deka, R

Underhill, P

Xiao, CJ

Shriver, M

Lell, J

Wallace, D

Wells, RS

Seielstad, M

Oefner, P

Zhu, DL

Jin, JZ

Huang, W

Chakraborty, R

Chen, Z

Jin, L

机构：

[1] Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200443, Peoples R China

[2] Morgan Tan Int Ctr Life Sci, Shanghai, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Zool, Kunming, Peoples R China

[4] Univ Texas, Ctr Human Genet, Houston, TX 77030 USA

[5] Eijkman Inst Mol Biol, Jakarta, Indonesia

[6] Univ Cincinnati, Dept Environm Hlth, Cincinnati, OH 45267 USA

[7] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[8] Yunnan Univ, Dept Biol, Kunming 650091, Peoples R China

[9] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA

[10] Emory Univ, Sch Med, Ctr Mol Med, Atlanta, GA 30322 USA

[11] Univ Oxford, WEllcome Trust Ctr Human Genet, Oxford OX1 2JD, England

[12] Harvard Univ, Sch Publ Hlth, Program Populat Genet, Boston, MA 02115 USA

[13] Shanghai Second Med Univ, Shanghai, Peoples R China

[14] Natl Human Genome Ctr, Shanghai, Peoples R China

来源：

SCIENCE | 2001年 / 292卷 / 5519期

关键词：

D O I：

10.1126/science.1060011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.

引用

页码：1151 / 1153

页数：3

共 29 条

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