Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability

被引：81

作者：

Bürkle, A ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Newcastle Gen Hosp, Wolfson Res Ctr, IHE,Inst Hlth Elderly,Dept Gerontol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

CANCER LETTERS | 2001年 / 163卷 / 01期

关键词：

DNA strand breaks; poly(ADP-ribose); DNA repair; genomic instability; cancer therapy; tumour cell resistance;

D O I：

10.1016/S0304-3835(00)00694-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activation of poly(ADP-ribose) polymerase-1 (PARP-1) is an immediate cellular reaction to DNA strand breakage as induced by alkylating agents, ionizing radiation or oxidants. The resulting formation of protein-coupled poly(ADP-ribose) facilitates survival of proliferating cells under conditions of DNA damage, probably via its contribution to DNA base-excision repair. Furthermore, based on recent results there is a role emerging for PARP-1 as a negative regulator of genomic instability in cells under genotoxic stress. Regarding possible applications for clinical cancer therapy with DNA-damaging agents, it appears that both inhibition and up-regulation of the poly(ADP-ribosyl)ation response in the malignant cells to be eradicated are promising strategies to improve the outcome of such therapy, albeit for different reasons. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

共 42 条

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