The HIV-1 envelope glycoproteins: Fusogens, antigens, and immunogens

被引：1289

作者：

Wyatt, R

Sodroski, J ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol AIDS,Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

SCIENCE | 1998年 / 280卷 / 5371期

关键词：

D O I：

10.1126/science.280.5371.1884

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1envelope glycoproteins and, ultimately, aid in HIV-1vaccine development.

引用

页码：1884 / 1888

页数：5

共 176 条

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