Direct Alkynylation of Thiophenes: Cooperative Activation of TIPS-EBX with Gold and Bronsted Acids

被引：179

作者：

Brand, Jonathan P. ^{[1
]}

Waser, Jerome ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Catalysis & Organ Synth, EPFL SB ISIC LCSO, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 40期

关键词：

alkynes; cooperative catalysis; direct alkynylation; heterocycles; hypervalent iodine; CATALYZED DIRECT ALKYNYLATION; FIELD-EFFECT TRANSISTORS; DIRECT ARYLATION; HYPERVALENT IODINE; TERMINAL ALKYNES; COPPER; TRIFLUOROMETHYLATION; ETHYNYLATION; HETEROCYCLES; ARENES;

D O I：

10.1002/anie.201003179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

United we stand! Cooperative activation of the hypervalent-iodine reagent TIPS-EBX with a gold catalyst and a Brønsted acid allowed the first direct ethynylation of thiophenes at room temperature (see scheme; TFA = trifluoroacetic acid). The obtained ethynylthiophenes are important building blocks for organic dyes and electronic materials. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7304 / 7307

页数：4

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