Granzyme B-induced cell death

被引：34

作者：

Andrade, F

Casciola-Rosen, LA

Rosen, A

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Cell Biol & Anat, Baltimore, MD 21205 USA

来源：

ACTA HAEMATOLOGICA | 2003年 / 111卷 / 1-2期

关键词：

apoptosis; caspase; CTL; cytotoxicity; granzyme B;

D O I：

10.1159/000074484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions. These include the uptake and trafficking of GrB within target cells, pathways used to trigger cell death, and the mechanism(s) controlling its killing activity. In addition, the role that GrB plays in human pathologies is still to be defined. The purpose of this review is to discuss recent insights into the biology of GrB and to evaluate its functional significance in health and disease. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：28 / 41

页数：14

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