Granzyme B-induced cell death

被引：34

作者：

Andrade, F

Casciola-Rosen, LA

Rosen, A

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, DF, Mexico

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Cell Biol & Anat, Baltimore, MD 21205 USA

来源：

ACTA HAEMATOLOGICA | 2003年 / 111卷 / 1-2期

关键词：

apoptosis; caspase; CTL; cytotoxicity; granzyme B;

D O I：

10.1159/000074484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Granzyme B (GrB) is a serine protease that is released by cytotoxic lymphocytes to kill virus-infected and tumor cells. Recent advances in the understanding of GrB have stressed the importance of reassessing the mechanisms by which GrB accomplishes its death functions. These include the uptake and trafficking of GrB within target cells, pathways used to trigger cell death, and the mechanism(s) controlling its killing activity. In addition, the role that GrB plays in human pathologies is still to be defined. The purpose of this review is to discuss recent insights into the biology of GrB and to evaluate its functional significance in health and disease. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：28 / 41

页数：14

共 187 条

[11] THE BACULOVIRUS P35 PROTEIN INHIBITS FAS-INDUCED AND TUMOR NECROSIS FACTOR-INDUCED APOPTOSIS
BEIDLER, DR
TEWARI, M
FRIESEN, PD
POIRIER, G
DIXIT, VM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16526 - 16528
[12] Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
Beresford, PJ
Zhang, D
Oh, DY
Fan, ZS
Greer, EL
Russo, ML
Jaju, M
Lieberman, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (46) : 43285 - 43293
[13] Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation
Beresford, PJ
Xia, ZN
Greenberg, AH
Lieberman, J
[J]. IMMUNITY, 1999, 10 (05) : 585 - 594
[14] Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
Bird, CH
Sutton, VR
Sun, JR
Hirst, CE
Novak, A
Kumar, S
Trapani, JA
Bird, PI
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) : 6387 - 6398
[15] Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
Bird, CH
Blink, EJ
Hirst, CE
Buzza, MS
Steele, PM
Sun, JR
Jans, SA
Bird, PI
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (16) : 5396 - 5407
[16] A NOVEL PROTEIN THAT INTERACTS WITH THE DEATH DOMAIN OF FAS/APO1 CONTAINS A SEQUENCE MOTIF RELATED TO THE DEATH DOMAIN
BOLDIN, MP
VARFOLOMEEV, EE
PANCER, Z
METT, IL
CAMONIS, JH
WALLACH, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) : 7795 - 7798
[17] Browne KA, 1999, MOL CELL BIOL, V19, P8604
[18] Biochemical pathways of caspase activation during apoptosis
Budihardjo, I
Oliver, H
Lutter, M
Luo, X
Wang, XD
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 : 269 - 290
[19] INHIBITION OF ICE FAMILY PROTEASES BY BACULOVIRUS ANTIAPOPTOTIC PROTEIN P35
BUMP, NJ
HACKETT, M
HUGUNIN, M
SESHAGIRI, S
BRADY, K
CHEN, P
FERENZ, C
FRANKLIN, S
GHAYUR, T
LI, P
LICARI, P
MANKOVICH, J
SHI, LF
GREENBERG, AH
MILLER, LK
WONG, WW
[J]. SCIENCE, 1995, 269 (5232) : 1885 - 1888
[20] The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses
Buzza, MS
Hirst, CE
Bird, CH
Hosking, P
McKendrick, J
Bird, PI
[J]. CELLULAR IMMUNOLOGY, 2001, 210 (01) : 21 - 29

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