Chromosomal changes in a dedifferentiated chondrosarcoma: a case report and review of the literature

被引：14

作者：

O'Malley, DP

Opheim, KE

Barry, TS

Chapman, DB

Emond, MJ

Conrad, EU

Norwood, TH ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA

[2] Loma Linda Univ, Med Ctr, Dept Pathol, Loma Linda, CA USA

[3] Univ Washington, Sch Med, Dept Pathol, Childrens Hosp & Reg Med Ctr, Seattle, WA 98195 USA

[4] Univ Washington, Sch Med, Dept Biostat, Seattle, WA 98195 USA

[5] Univ Washington, Sch Med, Dept Orthopaed, Seattle, WA 98195 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 2001年 / 124卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(00)00335-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chromosome abnormalities observed in a dedifferentiated chondrosarcoma are reported. A new molecular cytogenetic technique, spectral karyotyping, was used to identify and confirm structural rearrangements in this case. A review of the literature revealed that nine cases have been reported, in eight of which a complete description of the cytogenetic abnormalities was described. Structural aberrations were most frequently reported in chromosomes 1 and 9, and chromosomes 7 and 19 were most frequently observed to be involved in numerical aberrations (trisomy and tetrasomy). In chondrosarcomas, structural aberrations in chromosomes 1 and 9 and trisomy or tetrasomy of chromosome 7 are among the more frequently observed aberrations. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：105 / 111

页数：7