Nano-Layered Microneedles for Transcutaneous Delivery of Polymer Nanoparticles and Plasmid DNA

被引：154

作者：

DeMuth, Peter C.

Su, Xingfang

Samuel, Raymond E. ^{[1
]}

Hammond, Paula T. ^{[1
,2
]}

Irvine, Darrell J. ^{[3
,4
,5
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA

[3] MIT, Dept Mat Sci & Engn, Dept Biol Engn, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[4] Ragon Inst MIT MGH & Harvard, Boston, MA 02139 USA

[5] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 43期

关键词：

MULTILAYER FILMS; DRUG; MULTIPLE; RELEASE; CELLS;

D O I：

10.1002/adma.201001525

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer selfassembly and then delivered to the skin by microneedle application to achieve colocalization with Langerhans dendritic cells (MHC II-GFP-green).

引用

页码：4851 / +

页数：7

共 35 条

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Synthesis of poly(β-amino ester)s optimized for highly effective gene delivery [J].