Synthesis of an eight-membered cyclic pseudo-dipeptide using ring closing metathesis

被引：72

作者：

Creighton, CJ ^{[1
]}

Reitz, AB ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, Spring House, PA 19477 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 06期

关键词：

D O I：

10.1021/ol015530u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Ring closing metathesis of diallylglycine 6 provided cyclic Z-olefin 7 in 80% yield, The reaction was promoted by substitution of the amide nitrogen with the 2,4-dimethoxybenzyl group allowing for the required cis diallylglycine amide rotamer, Removal of the protecting groups provided cyclic dipeptide 2, a constrained scaffold useful in peptidomimetic research.

引用

页码：893 / 895

页数：3

共 39 条

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