Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis

被引：22

作者：

Daoud, Hussein ^{[1
]}

Valdmanis, Paul N. ^{[1
]}

Dion, Patrick A. ^{[1
]}

Rouleau, Guy A. ^{[1
]}

机构：

[1] Univ Montreal, Ctr Excellence Neur, Montreal, PQ, Canada

来源：

AMYOTROPHIC LATERAL SCLEROSIS | 2010年 / 11卷 / 04期

基金：

加拿大健康研究院;

关键词：

Amyotrophic lateral sclerosis; genetics; genome-wide association studies; DPP6; FGGY; GENETICS;

D O I：

10.3109/17482960903358857

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

DPP6 and FGGY genes have been recently associated with an increased susceptibility for sporadic amyotrophic lateral sclerosis. Here, we evaluated the role of these genes in ALS pathogenesis by undertaking a sequence analysis of a cohort of 190 ALS patients from France and Quebec. We did not observe any evidence that mutations in DPP6 and FGGY genes are involved in ALS. Our data indicate that mutations in these genes are unlikely to be a common cause of ALS in the French and French Canadian populations.

引用

页码：389 / 391

页数：3

共 8 条

[1]

A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis [J].

Chio, Adriano ;

Schymick, Jennifer C. ;

Restagno, Gabriella ;

Scholz, Sonja W. ;

Lombardo, Federica ;

Lai, Shiao-Lin ;

Mora, Gabriele ;

Fung, Hon-Chung ;

Britton, Angela ;

Arepalli, Sampath ;

Gibbs, J. Raphael ;

Nalls, Michael ;

Berger, Stephen ;

Kwee, Lydia Coulter ;

Oddone, Eugene Z. ;

Ding, Jinhui ;

Crews, Cynthia ;

Rafferty, Ian ;

Washecka, Nicole ;

Hernandez, Dena ;

Ferrucci, Luigi ;

Bandinelli, Stefania ;

Guralnik, Jack ;

Macciardi, Fabio ;

Torri, Federica ;

Lupoli, Sara ;

Chanock, Stephen J. ;

Thomas, Gilles ;

Hunter, David J. ;

Gieger, Christian ;

Wichmann, H. Erich ;

Calvo, Andrea ;

Mutani, Roberto ;

Battistini, Stefania ;

Giannini, Fabio ;

Caponnetto, Claudia ;

Mancardi, Giovanni Luigi ;

La Bella, Vincenzo ;

Valentino, Francesca ;

Monsurro, Maria Rosaria ;

Tedeschi, Gioacchino ;

Marinou, Kalliopi ;

Sabatelli, Mario ;

Conte, Amelia ;

Mandrioli, Jessica ;

Sola, Patrizia ;

Salvi, Fabrizio ;

Bartolomei, Ilaria ;

Siciliano, Gabriele ;

Carlesi, Cecilia .

HUMAN MOLECULAR GENETICS, 2009, 18 (08) :1524-1532

[2]

Screening for replication of genome-wide SNP associations in sporadic ALS [J].

Cronin, Simon ;

Tomik, Barbara ;

Bradley, Daniel G. ;

Slowik, Agnieszka ;

Hardiman, Orla .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2009, 17 (02) :213-218

[3]

Whole-genome analysis of sporadic amyotrophic lateral sclerosis [J].

Dunckley, Travis ;

Huentelman, Matthew J. ;

Craig, David W. ;

Pearson, John V. ;

Szelinger, Szabolcs ;

Joshipura, Keta ;

Halperin, Rebecca F. ;

Stamper, Chelsea ;

Jensen, Kendall R. ;

Letizia, David ;

Hesterlee, Sharon E. ;

Pestronk, Alan ;

Levine, Todd ;

Bertorini, Tulio ;

Graves, Michael C. ;

Mozaffar, Tahseen ;

Jackson, Carlayne E. ;

Bosch, Peter ;

McVey, April ;

Dick, Arthur ;

Barohn, Richard ;

Lomen-Hoerth, Catherine ;

Rosenfeld, Jeffrey ;

O'Connor, Daniel T. ;

Zhang, Kuixing ;

Crook, Richard ;

Ryberg, Henrik ;

Hutton, Michael ;

Katz, Jonathan ;

Simpson, Ericka P. ;

Mitsumoto, Hiroshi ;

Bowser, Robert ;

Miller, Robert G. ;

Appel, Stanley H. ;

Stephan, Dietrich A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (08) :775-788

[4]

Genetics - The elusive ALS genes [J].

Garber, Ken .

SCIENCE, 2008, 319 (5859) :20-20

[5]

The Proportion of Mutations Predicted To Have a Deleterious Effect Differs Between Gain and Loss of Function Genes in Neurodegenerative Disease [J].

Valdmanis, Paul N. ;

Verlaan, Dominique J. ;

Rouleau, Guy A. .

HUMAN MUTATION, 2009, 30 (03) :E481-E489

[6]

Recent advances in the genetics of amyotrophic lateral sclerosis [J].

Valdmanis, Paul N. ;

Daoud, Hussein ;

Dion, Patrick A. ;

Rouleau, Guy A. .

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2009, 9 (03) :198-205

[7]

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis [J].

van Es, Michael A. ;

van Vught, Paul Wj ;

Blauw, Hylke M. ;

Franke, Lude ;

Saris, Christiaan G. J. ;

Van Den Bosch, Ludo ;

de Jong, Sonja W. ;

de Jong, Vianney ;

Baas, Frank ;

van't Slot, Ruben ;

Lemmens, Robin ;

Schelhaas, Helenius J. ;

Birve, Anna ;

Sleegers, Kristel ;

Van Broeckhoven, Christine ;

Schymick, Jennifer C. ;

Traynor, Bryan J. ;

Wokke, John H. J. ;

Wijmenga, Cisca ;

Robberecht, Wim ;

Andersen, Peter M. ;

Veldink, Jan H. ;

Ophoff, Roel A. ;

van den Berg, Leonard H. .

NATURE GENETICS, 2008, 40 (01) :29-31

[8]

VANES MA, 2009, AMYOTROPH LATERAL SC, V19, P1

← 1 →