Asymmetric organocatalytic [3+2]-annulation strategy for the synthesis of N-fused heteroaromatic compounds

被引：53

作者：

Albrecht, Lukasz ^{[1
]}

Albrecht, Anna ^{[1
]}

Ransborg, Lars Krogager ^{[1
]}

Jorgensen, Karl Anker ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Ctr Catalysis, DK-8000 Aarhus C, Denmark

来源：

CHEMICAL SCIENCE | 2011年 / 2卷 / 07期

关键词：

ALPHA; BETA-UNSATURATED ALDEHYDES; ENANTIOSELECTIVE AZIRIDINATION; ANTIVIRAL ACTIVITY; SELECTIVE LIGANDS; BINDING-AFFINITY; EPOXIDATION; DERIVATIVES; POTENT; INHIBITORS; ACTIVATION;

D O I：

10.1039/c1sc00122a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxyalkyl- or aminoalkyl-substituted N-fused heteroaromatic compounds can be efficiently accessed via an organocatalytic [3 + 2]-annulation strategy. The developed cascades proceed in a highly enantioselective manner and benefit from broad substrate scope, operational simplicity, easily available starting materials as well as low catalyst loadings.

引用

页码：1273 / 1277

页数：5

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