Linking gene regulation to mRNA production and export

被引：95

作者：

Rodriguez-Navarro, Susana ^{[1
]}

Hurt, Ed ^{[2
]}

机构：

[1] Ctr Invest Principe Felipe, Valencia, Spain

[2] Heidelberg Univ, Zentrum Biochem, Heidelberg, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 03期

关键词：

UBIQUITIN-ASSOCIATED DOMAIN; NUCLEAR-PORE; TRANSCRIPTION ELONGATION; COUPLING TRANSCRIPTION; FUNCTIONAL COMPONENT; NUCLEOPORIN NUP214; MRNP DYNAMICS; BUDDING YEAST; THO COMPLEX; SAGA;

D O I：

10.1016/j.ceb.2010.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulation of gene expression can occur at many different levels. One important step in the gene expression process is the transport of mRNA from the nucleus to the cytoplasm. In recent years, studies have described how nuclear mRNA export depends on the steps preceding and following transport through nuclear pore complexes. These include gene activation, transcription, mRNA processing and mRNP assembly and disassembly. In this review, we summarise recent insights into the links between these steps in the gene expression cascade.

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收藏

页码：302 / 309

页数：8

相关论文

共 69 条

[1] Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes [J].

Abruzzi, KC ;

Lacadie, S ;

Rosbash, M .

EMBO JOURNAL, 2004, 23 (13) :2620-2631

[2] GENE GATING - A HYPOTHESIS [J].

BLOBEL, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8527-8529

[3]

Bolger Timothy A, 2008, Cell, V134, P624, DOI 10.1016/j.cell.2008.06.027

[4] Gene recruitment of the activated INO1 locus to the nuclear membrane [J].

Brickner, JH ;

Walter, P .

PLOS BIOLOGY, 2004, 2 (11) :1843-1853

[5] Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes [J].

Brown, Christopher R. ;

Kennedy, Caleb J. ;

Delmar, Valerie A. ;

Forbes, Douglass J. ;

Silver, Pamela A. .

GENES & DEVELOPMENT, 2008, 22 (05) :627-639

[6] SAGA interacting factors confine sub-diffusion of transcribed genes to the nuclear envelope [J].

Cabal, Ghislain G. ;

Genovesio, Auguste ;

Rodriguez-Navarro, Susana ;

Zimmer, Christophe ;

Gadal, Olivier ;

Lesne, Annick ;

Buc, Henri ;

Feuerbach-Fournier, Frank ;

Olivo-Marin, Jean-Christophe ;

Hurt, Eduard C. ;

Nehrbass, Ulf .

NATURE, 2006, 441 (7094) :770-773

[7] Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes [J].

Capelson, Maya ;

Liang, Yun ;

Schulte, Roberta ;

Mair, William ;

Wagner, Ulrich ;

Hetzer, Martin W. .

CELL, 2010, 140 (03) :372-U100

[8] The role of nuclear pores in gene regulation, development and disease [J].

Capelson, Maya ;

Hetzer, Martin W. .

EMBO REPORTS, 2009, 10 (07) :697-705

[9] The Mitogen-Activated Protein Kinase Slt2 Regulates Nuclear Retention of Non-Heat Shock mRNAs during Heat Shock-Induced Stress [J].

Carmody, Sean R. ;

Tran, Elizabeth J. ;

Apponi, Luciano H. ;

Corbett, Anita H. ;

Wente, Susan R. .

MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (21) :5168-5179

[10] Developmentally induced changes in transcriptional program alter spatial organization across chromosomes [J].

Casolari, JM ;

Brown, CR ;

Drubin, DA ;

Rando, OJ ;

Silver, PA .

GENES & DEVELOPMENT, 2005, 19 (10) :1188-1198

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