Complex translocation (7;22) identified in an epithelioid hemangioendothelioma

被引：41

作者：

Boudousquie, AC

Lawce, HJ

Sherman, R

Olson, S

Magenis, RE

Corless, CL

机构：

[1] OREGON HLTH SCI UNIV HOSP, DEPT PATHOL, PORTLAND, OR USA

[2] OREGON HLTH SCI UNIV HOSP, DEPT MOL & MED GENET, CLIN CYTOGENET LAB, PORTLAND, OR USA

[3] DEPT VET AFFAIRS MED CTR, DEPT PATHOL & LAB SERV, PORTLAND, OR USA

来源：

CANCER GENETICS AND CYTOGENETICS | 1996年 / 92卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(96)00175-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

We describe a malignant epithelioid hemangioendothelioma arising in the back of a 45-year-old man with pulmonary and bone marrow metastases. Light microscopic and immunohistochemical features of this tumor are presented. Karyotyping revealed several clonal abnormalities: a complex unbalanced translocation (7;22) involving multiple breakpoints (confirmed by fluorescence in situ hybridization), a Robertsonian t(14;14), and loss of the Y chromosome. Monosomy for chromosome 11 was noted in a subset of the tumor cells. To our knowledge a karyotype has not been previously reported for this unusual vascular tumor. (C) Elsevier Science Inc., 1996

引用

页码：116 / 121

页数：6

共 23 条

[1]

[Anonymous], 1992, Genes Chromosomes Cancer, V5, P83

[2]

EPITHELIOID HEMANGIOENDOTHELIOMA - REPORT OF A CASE WITH IMMUNO-LECTINHISTOCHEMICAL AND ULTRASTRUCTURAL DEMONSTRATION OF ITS VASCULAR NATURE [J].