Brain atrophy in relapsing-remitting multiple sclerosis:: Fractional volumetric analysis of gray matter and white matter

被引：79

作者：

Ge, YL

Grossman, RI

Udupa, JK

Babb, JS

Nyúl, LG

Kolson, DL

机构：

[1] Univ Penn, Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA

[3] Fox Chase Canc Ctr, Dept Biostat, Philadelphia, PA 19111 USA

来源：

RADIOLOGY | 2001年 / 220卷 / 03期

关键词：

brain; gray matter; MR; volume; white matter; sclerosis; multiple;

D O I：

10.1148/radiol.2203001776

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

PURPOSE: To determine the fractional brain tissue volume changes in the gray matter and white matter of patients with relapsing-remitting multiple sclerosis (MS) and to correlate these measurements with clinical disability and total lesion load. MATERIALS AND METHODS: Thirty patients with relapsing-remitting MS and 25 healthy control subjects underwent magnetic resonance imaging. Fractional brain tissue volumes (tissue volume relative to total intracranial volume) were obtained from the total segmented gray matter and white matter in each group and were analyzed. RESULTS: The fractional volume of white matter versus that of gray matter was significantly lower (-6.4%) in patients with MS (P < .0001) than in control subjects. Neither gray matter nor white matter fractional volume measurements correlated with clinical disability in the patients with MS. CONCLUSION: Loss of brain parenchymal volume in patients with relapsing-remitting MS is predominantly confined to white matter. Analysis of fractional brain tissue volumes provides additional information useful in characterizing MS and may have potential in evaluating treatment strategies.

引用

页码：606 / 610

页数：5

共 29 条

[21] A longitudinal study of brain atrophy in relapsing multiple sclerosis [J].

Simon, JH ;

Jacobs, LD ;

Campion, MK ;

Rudick, RA ;

Cookfair, DL ;

Herndon, RM ;

Richert, JR ;

Salazar, AM ;

Fischer, JS ;

Goodkin, DE ;

Simonian, N ;

Lajaunie, M ;

Miller, DE ;

Wende, K ;

Martens-Davidson, A ;

Kinkel, RP ;

Munschauer, FE ;

Brownscheidle, CM .

NEUROLOGY, 1999, 53 (01) :139-148

[22] SERIAL GADOLINIUM-ENHANCED MRI IN RELAPSING REMITTING MULTIPLE-SCLEROSIS OF VARYING DISEASE DURATION [J].

THOMPSON, AJ ;

MILLER, D ;

YOUL, B ;

MACMANUS, D ;

MOORE, S ;

KINGSLEY, D ;

KENDALL, B ;

FEINSTEIN, A ;

MCDONALD, WI .

NEUROLOGY, 1992, 42 (01) :60-63

[23] Axonal transection in the lesions of multiple sclerosis [J].

Trapp, BD ;

Peterson, J ;

Ransohoff, RM ;

Rudick, R ;

Mörk, S ;

Bö, L .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (05) :278-285

[24] Accumulation of hypointense lesions (''black holes'') on T-1 spin-echo MRI correlates with disease progression in multiple sclerosis [J].

Truyen, L ;

vanWaesberghe, JHTM ;

vanWalderveen, MAA ;

vanOosten, BW ;

Polman, CH ;

Hommes, OR ;

Ader, HJA ;

Barkhof, F .

NEUROLOGY, 1996, 47 (06) :1469-1476

[25] Multiple sclerosis lesion quantification using fuzzy-connectedness principles [J].

Udupa, JK ;

Wei, L ;

Samarasekera, S ;

Miki, Y ;

vanBuchem, MA ;

Grossman, RI .

IEEE TRANSACTIONS ON MEDICAL IMAGING, 1997, 16 (05) :598-609

[26]

UDUPA JK, 1994, P SOC PHOTO-OPT INS, V2164, P58, DOI 10.1117/12.174042

[27]

UDUPA JK, 1996, GRAPH MODEL IM PROC, V33, P480

[28] Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis [J].

van Walderveen, MAA ;

Kamphorst, W ;

Scheltens, P ;

van Waesberghe, JHTM ;

Ravid, R ;

Valk, J ;

Polman, CH ;

Barkhof, F .

NEUROLOGY, 1998, 50 (05) :1282-1288

[29]

ZIMMERMAN HM, 1948, RES PUBL ASSOC RES N, V28, P271

← 1 2 3 →