Molecular imaging of the lungs

被引:3
作者
Dharmarajan, S
Schuster, DP [1 ]
机构
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA
关键词
positron emission tomography; magnetic resonance imaging; optical imaging; inflammation imaging; gene expression imaging;
D O I
10.1016/j.acra.2005.07.005
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
An emerging suite of new imaging techniques offer the ability to monitor and quantify molecular and cellular processes in the lungs noninvasively. These techniques take advantage of dramatic advances in both imaging technology as well as molecular and cell biology. Molecular imaging is being used with increasing regularity in research protocols, and forms of molecular imaging have found their way into the patient care setting (eg, positron emission tomography imaging in cancer). Such techniques will afford the basic scientist as well as the clinician an unprecedented opportunity for in vivo study of the lung biology that drives normal pulmonary physiology as well as pathophysiology.
引用
收藏
页码:1394 / 1405
页数:12
相关论文
共 83 条
[11]  
Cherry S R, 2001, ILAR J, V42, P219
[12]  
CLARK R J, 1989, American Review of Respiratory Disease, V139, pA58
[13]   Photonic detection of bacterial pathogens in living hosts [J].
Contag, CH ;
Contag, PR ;
Mullins, JI ;
Spilman, SD ;
Stevenson, DK ;
Benaron, DA .
MOLECULAR MICROBIOLOGY, 1995, 18 (04) :593-603
[14]  
CURRIE DC, 1987, LANCET, V1, P1335
[15]   Visualization of the transgene distribution according to the administration route allows prediction of the transfection efficacy and validation of the results obtained [J].
Delepine, P ;
Montier, T ;
Guillaume, C ;
Vaysse, L ;
Le Pape, A ;
Ferec, C .
GENE THERAPY, 2002, 9 (11) :736-739
[16]  
DEWANJEE MK, 1994, J NUCL MED, V35, P1054
[17]   In vivo molecular imaging characterizes pulmonary gene expression during experimental lung transplantation [J].
Dharmarajan, S ;
Hayama, M ;
Kozlowski, J ;
Ishiyama, T ;
Okazaki, M ;
Factor, P ;
Patterson, GA ;
Schuster, DP .
AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 (06) :1216-1225
[18]   Advancing animal models of neoplasia through in vivo bioluminescence imaging [J].
Edinger, M ;
Cao, YA ;
Hornig, YS ;
Jenkins, DE ;
Verneris, MR ;
Bachmann, MH ;
Negrin, RS ;
Contag, CH .
EUROPEAN JOURNAL OF CANCER, 2002, 38 (16) :2128-2136
[19]   Evolving role of positron emission tomography in the management of patients with inflammatory and other benign disorders [J].
El-Haddad, G ;
Zhuang, HM ;
Gupta, N ;
Alavi, A .
SEMINARS IN NUCLEAR MEDICINE, 2004, 34 (04) :313-329
[20]   Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon [J].
Francis, KP ;
Yu, J ;
Bellinger-Kawahara, C ;
Joh, D ;
Hawkinson, MJ ;
Xiao, G ;
Purchio, TF ;
Caparon, MG ;
Lipsitch, M ;
Contag, PR .
INFECTION AND IMMUNITY, 2001, 69 (05) :3350-3358