Gene polymorphisms and their effects in the melanocortin system

被引：23

作者：

Carroll, L ^{[1
]}

Voisey, J ^{[1
]}

van Daal, A ^{[1
]}

机构：

[1] Queensland Univ Technol, CRC Diagnost, Brisbane, Qld 4000, Australia

来源：

PEPTIDES | 2005年 / 26卷 / 10期

关键词：

polymorphism; SNP; agouti; melanocortin;

D O I：

10.1016/j.peptides.2004.12.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In addition to its role in human pigmentation, components of the melanocortin system regulate appetite, energy homeostasis and hormone production. Recent studies have suggested possible roles of this system in immunity, transmission of pain signals, and reproductive potential. A number of polymorphisms have been identified in genes of the melanocortin system and are associated with pigmentation in humans, as well as being causative of disorders of adrenal hormone production and obesity. This review gives an outline of these polymorphisms, their functional significance and possible application to or impact on diagnosis and pharmacotherapy based on melanocortin pathways. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1871 / 1885

页数：15

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