E4BP4: an unexpected player in the immune response

被引：89

作者：

Male, Victoria ^{[1
]}

Nisoli, Ilaria ^{[1
]}

Gascoyne, Duncan M. ^{[2
]}

Brady, Hugh J. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Div Cell & Mol Biol, Sect Immunol & Infect, London SW7 2AZ, England

[2] Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford OX3 9DU, England

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 02期

基金：

英国医学研究理事会;

关键词：

NATURAL-KILLER-CELL; TRANSCRIPTION FACTOR E4BP4; GENE-EXPRESSION; IDENTIFICATION; REGULATOR; REQUIRES; PATHWAY; DIFFERENTIATION; COMMITMENT; REPRESSION;

D O I：

10.1016/j.it.2011.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Until recently, the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) was of little interest to immunologists, being best known for its role in regulating circadian rhythm in chick pineal gland. However, characterisation of E4bp4(-/-) mice, independently generated in four different laboratories, has revealed roles for E4BP4 in diverse haematopoietic lineages. E4BP4 is essential for the development of NK cells and CD8 alpha(+) conventional dendritic cells, and is also involved in macrophage activation, polarisation of CD4(+) T cell responses and B cell class switching to IgE. Here, we discuss the role of E4BP4 as a regulator of the immune response and highlight future questions for the field.

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页码：98 / 102

页数：5

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