Conformational analysis of meropenem and desmethyl meropenem: The effect of 1 beta-methyl group on carbapenem antibiotics

被引：4

作者：

Igarashi, J ^{[1
]}

Nishimura, T ^{[1
]}

Sasaki, A ^{[1
]}

Sunagawa, M ^{[1
]}

机构：

[1] SUMITOMO PHARMACEUT CO LTD,RES CTR,KONOHANA KU,OSAKA 554,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00341-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The conformations of meropenem and desmethyl meropenem have been studied using MM calculations and H-1 NMR experiments. It was found that the preferred conformation of meropenem was relatively Linear compared with desmethyl meropenem in aqueous solution. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1881 / 1886

页数：6

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