Axonal flip-flops and oscillators

被引：32

作者：

Baker, MD ^{[1
]}

机构：

[1] UCL, Dept Biol, London WC1E 6BT, England

来源：

TRENDS IN NEUROSCIENCES | 2000年 / 23卷 / 11期

关键词：

D O I：

10.1016/S0166-2236(00)01645-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such as multiple sclerosis. A build-up of extracellular K+ in the internode and persistent Na+ currents are now implicated in generating the different forms of activity arising in normal and demyelinated axons.

引用

页码：514 / 519

页数：6

共 43 条

[1] The efftects of injury on mammalian nerve fibres
Adrian, ED
[J]. PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER, 1930, 106 (747) : 596 - 618
[2] ECTOPIC ACTIVITY IN DEMYELINATED SPINAL ROOT AXONS OF THE RAT
BAKER, M
BOSTOCK, H
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1992, 451 : 539 - 552
[3] BAKER M, 1987, J PHYSIOL-LONDON, V383, P45
[4] Inactivation of macroscopic late Na+ current and characteristics of unitary late Na+ currents in sensory neurons
Baker, MD
Bostock, H
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1998, 80 (05) : 2538 - 2549
[5] Selective block of late Na+ current by local anaesthetics in rat large sensory neurones
Baker, MD
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129 (08) : 1617 - 1626
[6] INTRACELLULAR-RECORDING FROM VERTEBRATE MYELINATED AXONS - MECHANISM OF THE DEPOLARIZING AFTERPOTENTIAL
BARRETT, EF
BARRETT, JN
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1982, 323 (FEB): : 117 - 144
[7] Bergmans J., 1970, PHYSL SINGLE HUMAN N
[8] INTERNODAL AXON MEMBRANE - ELECTRICAL EXCITABILITY AND CONTINUOUS CONDUCTION IN SEGMENTAL DEMYELINATION
BOSTOCK, H
SEARS, TA
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1978, 280 (JUL): : 273 - 301
[9] CHANGES IN EXCITABILITY OF HUMAN MOTOR AXONS UNDERLYING POSTISCHEMIC FASCICULATIONS - EVIDENCE FOR 2 STABLE STATES
BOSTOCK, H
BAKER, M
REID, G
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1991, 441 : 537 - 557
[10] THE EFFECTS OF 4-AMINOPYRIDINE AND TETRAETHYLAMMONIUM IONS ON NORMAL AND DEMYELINATED MAMMALIAN NERVE-FIBERS
BOSTOCK, H
SEARS, TA
SHERRATT, RM
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1981, 313 (APR): : 301 - 315

← 1 2 3 4 5 →