Axonal flip-flops and oscillators

被引：32

作者：

Baker, MD ^{[1
]}

机构：

[1] UCL, Dept Biol, London WC1E 6BT, England

来源：

TRENDS IN NEUROSCIENCES | 2000年 / 23卷 / 11期

关键词：

D O I：

10.1016/S0166-2236(00)01645-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such as multiple sclerosis. A build-up of extracellular K+ in the internode and persistent Na+ currents are now implicated in generating the different forms of activity arising in normal and demyelinated axons.

引用

页码：514 / 519

页数：6

共 43 条

[11] Latent addition in motor and sensory fibres of human peripheral nerve
Bostock, H
Rothwell, JC
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1997, 498 (01): : 277 - 294
[12] POSTTETANIC EXCITABILITY CHANGES AND ECTOPIC DISCHARGES IN A HUMAN MOTOR AXON
BOSTOCK, H
BERGMANS, J
[J]. BRAIN, 1994, 117 : 913 - 928
[13] PHYSIOLOGICAL-EFFECTS OF 4-AMINOPYRIDINE ON DEMYELINATED MAMMALIAN MOTOR AND SENSORY FIBERS
BOWE, CM
KOCSIS, JD
TARG, EF
WAXMAN, SG
[J]. ANNALS OF NEUROLOGY, 1987, 22 (02) : 264 - 268
[14] Sodium channel Nav1.6 is localized at nodes of Ranvier, dendrites, and synapses
Caldwell, JH
Schaller, KL
Lasher, RS
Peles, E
Levinson, SR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) : 5616 - 5620
[15] Persistent sodium current in mammalian central neurons
Crill, WE
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 1996, 58 : 349 - 362
[16] CULP WJ, 1983, ABNORMAL NERVES MUSC, P4490
[17] MORPHOLOGY NEURAL NETWORKS - AN INTRODUCTION WITH APPLICATIONS
DAVIDSON, JL
HUMMER, F
[J]. CIRCUITS SYSTEMS AND SIGNAL PROCESSING, 1993, 12 (02) : 177 - 210
[18] ACTION POTENTIAL IN MYELINATED NERVE FIBRE OF XENOPUS LAEVIS AS COMPUTED ON BASIS OF VOLTAGE CLAMP DATA
FRANKENHAEUSER, B
HUXLEY, AF
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1964, 171 (02): : 302 - &
[19] THE AFTER-EFFECTS OF IMPULSES IN THE GIANT NERVE FIBRES OF LOLIGO
FRANKENHAEUSER, B
HODGKIN, AL
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1956, 131 (02): : 341 - 376
[20] METABOLIC STUDIES ON HYPERPOLARIZATION FOLLOWING ACTIVITY IN MAMMALIAN NON-MYELINATED NERVE FIBRES
GREENGARD, P
STRAUB, RW
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1962, 161 (03): : 414 - &

← 1 2 3 4 5 →