Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria

被引：32

作者：

Ottenhoff, THM

de Boer, T

Verhagen, CE

Verreck, FAW

van Dissel, JT

机构：

[1] Leiden Univ, Med Ctr, Dept Immunohematol & Blood Transfus, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Infect Dis, NL-2300 RC Leiden, Netherlands

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 13期

关键词：

interferon-gamma; interleukin-12; mycobacteria; Salmonella; granuloma; mutation; deletion;

D O I：

10.1016/S1286-4579(00)01312-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies on patients with idiopathic, severe infections due to poorly pathogenic mycobacteria and Salmonella have revealed that many of these patients are unable to produce or respond to interferon-gamma (IFN-gamma). This inability results from causative, deleterious genetic mutations in either one of four different genes in the type 1 cytokine cascade, encoding interleukin-12R beta1 (IL-12R beta1), IL-12p40, IFN-gamma R1 or IFN-gamma R2. The immunological phenotypes resulting from the seven groups of complete or partial deficiencies in type 1 cytokine (receptor) genes that have been distinguished thus far will be summarized and discussed, and placed in a broader context in relation to disease susceptibility. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1559 / 1566

页数：8