The problem of plain vanilla peptides

被引：16

作者：

Davis, MM ^{[1
]}

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/ni0703-649

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anti-influenza CD8(+) T cell response in HLA-A2 adults is dominated by a specific TCR. The crystal structure of the TCR and peptide-MHC complex show unusual interactions that help to explain the molecular basis of this dominant TCR selection.

引用

页码：649 / 650

页数：2

共 12 条

[1] Distinct molecular mechanisms account for the specificity of two different T-cell receptors [J].

Anikeeva, N ;

Lebedeva, T ;

Krogsgaard, M ;

Tetin, SY ;

Martinez-Hackert, E ;

Kalams, SA ;

Davis, MM ;

Sykulev, Y .

BIOCHEMISTRY, 2003, 42 (16) :4709-4716

[2] Not just any T cell receptor will do [J].

Bankovich, AJ ;

Garcia, KC .

IMMUNITY, 2003, 18 (01) :7-11

[3] Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus in vivo [J].

Callan, MFC ;

Tan, L ;

Annels, N ;

Ogg, GS ;

Wilson, JDK ;

O'Callaghan, CA ;

Steven, N ;

McMichael, AJ ;

Rickinson, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (09) :1395-1402

[4] Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 [J].

Garboczi, DN ;

Ghosh, P ;

Utz, U ;

Fan, QR ;

Biddison, WE ;

Wiley, DC .

NATURE, 1996, 384 (6605) :134-141

[5] Structure of a complex of the human α/β T cell receptor (TCR) HA1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB1*0401):: Insight into TCR cross-restriction and alloreactivity [J].

Hennecke, J ;

Wiley, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :571-581

[6] MAPPING T-CELL RECEPTOR PEPTIDE CONTACTS BY VARIANT PEPTIDE IMMUNIZATION OF SINGLE-CHAIN TRANSGENICS [J].

JORGENSEN, JL ;

ESSER, U ;

FAZEKAS DE ST GROTH, B ;

REAY, PA ;

DAVIS, MM .

NATURE, 1992, 355 (6357) :224-230

[7] A structural basis for the selection of dominant αβ T cell receptors in antiviral immunity [J].

Kjer-Nielsen, L ;

Clements, CS ;

Purcell, AW ;

Brooks, AG ;

Whisstock, JC ;

Burrows, SR ;

McCluskey, J ;

Rossjohn, J .

IMMUNITY, 2003, 18 (01) :53-64

[8] HUMAN HLA-A0201-RESTRICTED CYTOTOXIC T-LYMPHOCYTE RECOGNITION OF INFLUENZA-A IS DOMINATED BY T-CELLS BEARING THE V-BETA-17 GENE SEGMENT [J].

LEHNER, PJ ;

WANG, ECY ;

MOSS, PAH ;

WILLIAMS, S ;

PLATT, K ;

FRIEDMAN, SM ;

BELL, JI ;

BORYSIEWICZ, LK .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :79-91

[9] THE BASICS OF BINDING - MECHANISMS OF ANTIGEN RECOGNITION AND MIMICRY BY ANTIBODIES [J].

MARIUZZA, RA ;

POLJAK, RJ .

CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (01) :50-55

[10] EXTENSIVE CONSERVATION OF ALPHA-CHAIN AND BETA-CHAIN OF THE HUMAN T-CELL ANTIGEN RECEPTOR RECOGNIZING HLA-A2 AND INFLUENZA-A MATRIX PEPTIDE [J].

MOSS, PAH ;

MOOTS, RJ ;

ROSENBERG, WMC ;

ROWLANDJONES, SJ ;

BODMER, HC ;

MCMICHAEL, AJ ;

BELL, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) :8987-8990

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