Cerebellar activity and disturbed time sense after THC

被引：69

作者：

Mathew, RJ ^{[1
]}

Wilson, WH ^{[1
]}

Turkington, TG ^{[1
]}

Coleman, RE ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Psychiat & Radiol, Durham, NC 27710 USA

来源：

BRAIN RESEARCH | 1998年 / 797卷 / 02期

关键词：

tetrahydrocannabinol; cerebral blood flow; positron emission tomography; cerebral metabolism; temporal disintegration; cerebellum; anterior cingulate;

D O I：

10.1016/S0006-8993(98)00375-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Because marijuana continues to be the most commonly used illicit drug, its effects on the brain function are of major interest. We utilized positron emission tomography (PET) and magnetic resonance imaging (MRI) to study the effects of delta-9-tetrahydrocannabinol (THC) infusion on brain blood flow and its behavioral correlates in 46 volunteers. Consistent with previous reports, there was a significant increase in cortical and cerebellar blood flow following THC, but not all subjects showed this effect. Those who showed a decrease in cerebellar CBF also had a significant alteration in time sense. The relationship between decreased cerebellar flow and impaired time sense is of interest because the cerebellum has been linked to an internal timing system. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：183 / 189

页数：7

共 51 条

[1] NEUROBIOLOGY OF MARIJUANA ABUSE [J].

ABOOD, ME ;

MARTIN, BR .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (05) :201-206

[2]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[3] SCREENING DEPRESSED PATIENTS IN FAMILY PRACTICE - RAPID TECHNIQUE [J].

BECK, AT ;

BECK, RW .

POSTGRADUATE MEDICINE, 1972, 52 (06) :81-&

[4]

BRILL H, 1984, MARIJUANA SCI MED

[5] Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method [J].

Byrum, CE ;

MacFall, JR ;

Charles, HC ;

Chitilla, VR ;

Boyko, OB ;

Upchurch, L ;

Smith, JS ;

Rajagopalan, P ;

Passe, T ;

Kim, D ;

Xanthakos, S ;

Ranga, K ;

Krishnan, R .

PSYCHIATRY RESEARCH-NEUROIMAGING, 1996, 67 (03) :215-234

[6]

CLARK L D, 1970, Archives of General Psychiatry, V23, P193

[7] CEREBELLAR CONTRIBUTIONS TO COGNITION [J].

DAUM, I ;

ACKERMANN, H .

BEHAVIOURAL BRAIN RESEARCH, 1995, 67 (02) :201-210

[8] METHOD FOR QUANTIFICATION OF BRAIN, VENTRICULAR, AND SUBARACHNOID CSF VOLUMES FROM MR IMAGES [J].

DECARLI, C ;

MAISOG, J ;

MURPHY, DGM ;

TEICHBERG, D ;

RAPOPORT, SI ;

HORWITZ, B .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1992, 16 (02) :274-284

[9]

Dichgans J., 1984, Cerebellar Functions, P126, DOI [10.1007/978-3-642-69980-1_9, DOI 10.1007/978-3-642-69980-1_9]

[10] DEPERSONALIZATION PHENOMENA IN A SAMPLE-POPULATION OF COLLEGE-STUDENTS [J].

DIXON, JC .

BRITISH JOURNAL OF PSYCHIATRY, 1963, 109 (460) :371-&

← 1 2 3 4 5 6 →