Recent advances in androgen receptor action

被引：138

作者：

Lee, HJ

Chang, C

机构：

[1] Univ Rochester, George H Whipple Lab Canc Res, Dept Pathol, Rochester, NY 14642 USA

[2] Univ Rochester, George H Whipple Lab Canc Res, Dept Urol, Rochester, NY 14642 USA

[3] Univ Rochester, George H Whipple Lab Canc Res, Dept Radiat Oncol, Rochester, NY 14642 USA

[4] Univ Rochester, Ctr Canc, Rochester, NY 14642 USA

[5] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

[6] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2003年 / 60卷 / 08期

关键词：

androgen; coactivator; nuclear receptor;

D O I：

10.1007/s00018-003-2309-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Androgens, principally testosterone and 5alpha-di-hydrotestosterone, play critical roles in the development and growth of the male reproductive and nonreproductive systems. Their biological actions are mediated by the androgen receptor (AR), a ligand-dependent transcription factor, belonging to the nuclear receptor superfamily. These androgen-AR complexes interact with various factors (e.g. coactivators or corepressors) to modulate transcription of androgen target genes via specific DNA sequences. Many lines of evidence have also correlated AR with several mammalian disorders. Finally, recent advances in molecular biology have significantly impacted our knowledge of the role of AR in mammals. The aim of this review is to present recent emerging aspects of AR action.

引用

页码：1613 / 1622

页数：10

共 90 条

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