The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-Independent mechanism

被引：44

作者：

Dosch, T

Horn, F

Schneider, G

Krätzer, F

Dobner, T

Hauber, J

Stauber, RH

机构：

[1] Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91054 Erlangen, Germany

[2] Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 12期

关键词：

D O I：

10.1128/JVI.75.12.5677-5683.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viral mRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells, Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen the potential role of E1B-55K as the "driving force" for adenoviral late mRNA export.

引用

页码：5677 / 5683

页数：7

共 34 条

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