Three-dimensional magnetic resonance-based morphometrics and ventricular dysmorphology in schizophrenia

被引:25
作者
Buckley, PF
Dean, D
Bookstein, FL
Friedman, L
Kwon, D
Lewin, JS
Kamath, J
Lys, C
机构
[1] Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Neurol Surg, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Radiol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
[5] Nortcoast Behav Healthcare Syst, Cleveland, OH USA
[6] Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USA
关键词
neuroimaging; morphometrics; cerebral ventricles; schizophrenia;
D O I
10.1016/S0006-3223(98)00067-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Recent methodological refinements in magnetic resonance (MR) imaging have led to brain averaging and morphometric approaches that are sensitive to subtle anatomical distinctions in schizophrenia, Methods: Using a novel morphometric technique for surface analysis, 48 selected landmarks of the rendered ventricular system were extracted and compared between the ventricles of 20 patients with schizophrenia and 20 normal subjects, Results: There was no significant difference in ventricular shape between groups, but significant (p =.015) and highly localized shape deformity was detected at the foramen of Monro and at the proximal temporal ham of the lateral ventricle of male (but not female) patients relative to controls. Conclusions: Three-dimensional MR-based morphometrics complements established volumetric approaches and can detect minute shape deformities that may be associated with schizophrenia. Biol Psychiatry 1999;45: 62-67 (C) 1999 Society of Biological Psychiatry.
引用
收藏
页码:62 / 67
页数:6
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