Recent advances in chemical approaches to the study of biological systems

被引：85

作者：

Shogren-Knaak, MA ^{[1
]}

Alaimo, PJ

Shokat, KM

机构：

[1] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY | 2001年 / 17卷

关键词：

chemical genetics; combinatorial chemistry; enzyme inhibitors; protein-protein interactions; unnatural biopolymers;

D O I：

10.1146/annurev.cellbio.17.1.405

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A number of novel chemical methods for studying biological systems have recently been developed that provide a means of addressing biological questions not easily studied with other techniques. In this review, examples that highlight the development and use of such chemical approaches are discussed. Specifically, strategies for modulating protein activity or protein-protein interactions using small molecules are presented. In addition, methods for generating and utilizing novel biomolecules (proteins, oligonucleotides, oligosaccharides, and second messengers) are examined.

引用

页码：405 / 433

页数：33

共 114 条

[31] Designing small-molecule switches for protein-protein interactions
Guo, ZH
Zhou, DM
Schultz, PG
[J]. SCIENCE, 2000, 288 (5473) : 2042 - +
[32] ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation
Habelhah, H
Shah, K
Huang, L
Ostareck-Lederer, A
Burlingame, AL
Shokat, KM
Hentze, MW
Ronai, Z
[J]. NATURE CELL BIOLOGY, 2001, 3 (03) : 325 - 330
[33] Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor - Study of Lck- and FynT-dependent T cell activation
Hanke, JH
Gardner, JP
Dow, RL
Changelian, PS
Brissette, WH
Weringer, EJ
Pollok, K
Connelly, PA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) : 695 - 701
[34] The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain
Heinrich, SU
Mothes, W
Brunner, J
Rapoport, TA
[J]. CELL, 2000, 102 (02) : 233 - 244
[35] Dimeric ligands define a role for transcriptional activation domains in reinitiation
Ho, SN
Biggar, SR
Spencer, DM
Schreiber, SL
Crabtree, GR
[J]. NATURE, 1996, 382 (6594) : 822 - 826
[36] SIGNAL-TRANSDUCTION IN T-LYMPHOCYTES USING A CONDITIONAL ALLELE OF SOS
HOLSINGER, LJ
SPENCER, DM
AUSTIN, DJ
SCHREIBER, SL
CRABTREE, GR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (21) : 9810 - 9814
[37] Structure of unliganded HIV-1 reverse transcriptase at 2.7 angstrom resolution: Implications of conformational changes for polymerization and inhibition mechanisms
Hsiou, Y
Ding, J
Das, K
Clark, AD
Hughes, SH
Arnold, E
[J]. STRUCTURE, 1996, 4 (07) : 853 - 860
[38] Structure of a covalently trapped catalytic complex of HIV-I reverse transcriptase: Implications for drug resistance
Huang, HF
Chopra, R
Verdine, GL
Harrison, SC
[J]. SCIENCE, 1998, 282 (5394) : 1669 - 1675
[39] Trapping of a catalytic HIV reverse transcriptase•template:primer complex through a disulfide bond
Huang, HF
Harrison, SC
Verdine, GL
[J]. CHEMISTRY & BIOLOGY, 2000, 7 (05): : 355 - 364
[40] Signaling - 2000 and beyond
Hunter, T
[J]. CELL, 2000, 100 (01) : 113 - 127

← 1 2 3 4 5 6 7 8 9 10 →