A murine model of prenatal cocaine exposure: Effects on the mother and the fetus

被引:14
作者
Middaugh, LD
Boggan, WO
Bingel, SA
Patrick, KS
Xu, WD
机构
[1] MED UNIV S CAROLINA, DEPT COMPARAT MED, CHARLESTON, SC 29425 USA
[2] MED UNIV S CAROLINA, DEPT PHARMACEUT SCI, CHARLESTON, SC 29425 USA
关键词
prenatal cocaine; C57BL/6J mice; cocaine pathology; intrauterine growth reduction;
D O I
10.1016/S0091-3057(96)00250-X
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
To develop and characterize a murine model for investigating the long-term effects of prenatal cocaine exposure. the present study established the route of drug administration and the doses to be used for pregnant C57BL/6 mice. Comparison of the effects of a high dose of cocaine (60 mg/kg) when gavaged or injected subcutaneously (SC) established patterns of pathology characteristic of administration route but no dominating logic for selecting one over the other route for prenatal studies; however, because of the fourfold greater brain levels, with no evidence of greater pathology, the SC route was selected. When injected daily during gestation days 12-18, the period of prenatal development of dopamine systems, cocaine at doses producing plasma concentrations consistent with its stimulatory effects reduced food ingestion and weight gains during pregnancy and fetal body and brain weights at term. The extent of these reductions was comparable to reports on babies exposed to cocaine prenatally. Furthermore, the present study suggests that maternal undernutrition is not a likely mediator of these perinatal effects and that differences in the amount of cocaine exposure may cause the contrasting effects of maternal cocaine noted in the human literature. Copyright (C) 1996 Elsevier Science Inc.
引用
收藏
页码:565 / 574
页数:10
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