PRENATAL COCAINE EXPOSURE - DECREASED SENSITIZATION TO COCAINE AND DECREASED STRIATAL DOPAMINE TRANSPORTER BINDING IN OFFSPRING

被引：48

作者：

BYRNES, JJ ^{[1
]}

PRITCHARD, GA ^{[1
]}

KOFF, JM ^{[1
]}

MILLER, LG ^{[1
]}

机构：

[1] TUFTS UNIV, SCH MED, DEPT PHARMACOL & EXPTL THERAPEUT, BOSTON, MA 02111 USA

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 07期

关键词：

COCAINE; PRENATAL; DOPAMINE TRANSPORTER; DOPAMINE;

D O I：

10.1016/0028-3908(93)90087-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pregnant mice were treated with cocaine, 10 mg/kg/day, during days 13 to 20 of gestation. Cocaine sensitization and dopamine transporter binding were evaluated in offspring at 6 weeks of age. Sensitization, defined as the increase in activity after 5 injections of cocaine compared to 1 injection, was reduced in cocaine-exposed mice. Dopamine transporter binding in striatum was also significantly reduced in cocaine-exposed mice compared to controls.

引用

页码：721 / 723

页数：3

共 6 条

[1] BEHAVIORAL TERATOGENESIS - CRITICAL EVALUATION
COYLE, I
WAYNER, MJ
SINGER, G
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1976, 4 (02) : 191 - 200
[2] STRUCTURAL AND FUNCTIONAL-EFFECTS OF PRENATAL COCAINE EXPOSURE IN ADULT-RAT BRAIN
DOWEDWARDS, DL
FREED, LA
FICO, TA
[J]. DEVELOPMENTAL BRAIN RESEARCH, 1990, 57 (02): : 263 - 268
[3] Kuhar M J, 1988, NIDA Res Monogr, V88, P14
[4] POGUN S, 1991, EUR J PHARMACOL, V198, P203
[5] NEUROBEHAVIORAL SEQUELAE OF FETAL COCAINE EXPOSURE
SINGER, LT
GARBER, R
KLIEGMAN, R
[J]. JOURNAL OF PEDIATRICS, 1991, 119 (04) : 667 - 671
[6] COCAINE EFFECTS ON THE DEVELOPING CENTRAL NERVOUS-SYSTEM - BEHAVIORAL, PSYCHOPHARMACOLOGICAL, AND NEUROCHEMICAL STUDIES
SPEAR, LP
KIRSTEIN, CL
FRAMBES, NA
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1989, 562 : 290 - 307

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