Age-related cognitive decline: Can neural stem cells help us?

被引：57

作者：

Artegiani, Benedetta

Calegari, Federico ^{[1
]}

机构：

[1] Tech Univ Dresden, DFG Res Ctr & Cluster Excellence Regenerat Therap, Fac Med, D-01062 Dresden, Germany

来源：

AGING-US | 2012年 / 4卷 / 03期

关键词：

adult neurogenesis; neural stem cells; aging; regenerative therapies; GROWTH-FACTOR-I; ADULT HIPPOCAMPAL NEUROGENESIS; CEREBRAL-BLOOD-FLOW; STROKE-INDUCED NEUROGENESIS; DENTATE GYRUS; VASCULAR NICHE; GRANULE CELLS; DOPAMINERGIC DIFFERENTIATION; STIMULATES NEUROGENESIS; CALORIC RESTRICTION;

D O I：

10.18632/aging.100446

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Several studies suggest that an increase in adult neurogenesis has beneficial effects on emotional behavior and cognitive performance including learning and memory. The observation that aging has a negative effect on the proliferation of neural stem cells has prompted several laboratories to investigate new systems to artificially increase neurogenesis in senescent animals as a means to compensate for age-related cognitive decline. In this review we will discuss the systemic, cellular, and molecular changes induced by aging and affecting the neurogenic niche at the level of neural stem cell proliferation, their fate change, neuronal survival, and subsequent integration in the neuronal circuitry. Particular attention will be given to those manipulations that increase neurogenesis in the aged brain as a potential avenue towards therapy.

引用

页码：176 / 186

页数：11

共 153 条

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