Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia

被引：83

作者：

Kim, YO

Leem, K

Park, J

Lee, P

Ahn, DK

Lee, BC

Park, HK

Suk, K

Kim, SY

Kim, H

机构：

[1] Kyung Hee Univ, Grad Sch E W Med Sci, Dept Herbal Pharmacol, Tongdaemun Ku, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Oriental Med, Seoul 130701, South Korea

[3] Woosuk Univ, Coll Pharm, Dept Herbal Pharmacol, Chonju 565701, South Korea

[4] Korea Inst Sci & Technol, Seoul 130650, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2001年 / 77卷 / 2-3期

关键词：

neuroprotection; Scutellaria baicalensis; ischemia; TNF-alpha;

D O I：

10.1016/S0378-8741(01)00283-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CAI neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-alpha) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：183 / 188

页数：6

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[11] Ischemic brain injury and the therapeutic window [J].