Cognitive, physiological, and personality correlates of recurrence of depression

被引:30
作者
Bos, EH
Bouhuys, AL
Geerts, E
Van Os, TWDP
Van der Spoel, ID
Brouwer, WH
Ormel, J
机构
[1] Univ Groningen, Med Ctr, Dept Psychiat, NL-9700 RB Groningen, Netherlands
[2] Mental Hlth Care Friesland, Leeuwarden, Netherlands
[3] Univ Groningen, Med Ctr, Dept Psychol, NL-9700 RB Groningen, Netherlands
关键词
depression; recurrence; auditory perception; cortisol; neuroticism; gender;
D O I
10.1016/j.jad.2005.04.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The risk of recurrence in depressive disorder is high and increases with the number of episodes. We investigated whether individuals with a history of recurrent depression deviate from individuals with a single episode, as regards risk-related variables in 3 different domains of depression research. Methods: Participants were 102 outpatients with major depressive disorder remitted from an episode (60 recurrent, 42 nonrecurrent). We assessed the perception of emotions from vocal stimuli, 24-h urinary free cortisol, and neuroticism. Results: The recurrent group had higher cortisol levels than the nonrecurrent group, and recurrent women also had a more negative perception than nonrecurrent women. These results were independent of each other, and could also not be accounted for by neuroticism or residual symptoms. Gender differences were found in all 3 domains. Limitations: The cross-sectional design limits the possibility to draw conclusions on the causality of the observed effects. Conclusions: Remitted outpatients with recurrent depression deviate from remitted outpatients with single episode depression as regards physiology and social cognition, in a way that may increase their risk of the development of subsequent episodes. The results may have implications for prophylactic treatment strategies. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:221 / 229
页数:9
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