Gut feelings: the emerging biology of gut-brain communication

被引：1119

作者：

Mayer, Emeran A. ^{[1
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机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Neurobiol Stress, Div Digest Dis,Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Neurobiol Stress, Div Digest Dis,Dept Physiol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Neurobiol Stress, Div Digest Dis,Dept Psychiat, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2011年 / 12卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ENTERIC NERVOUS-SYSTEM; INFLAMMATORY-BOWEL-DISEASE; MEDIAL PREFRONTAL CORTEX; PRIMARY AFFERENT NEURONS; FUNCTIONAL GI-DISORDERS; PHYSIOLOGICAL CONDITION; SENSORY NEURONS; HUMAN INSULA; PAIN; RECEPTORS;

D O I：

10.1038/nrn3071

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The concept that the gut and the brain are closely connected, and that this interaction plays an important part not only in gastrointestinal function but also in certain feeling states and in intuitive decision making, is deeply rooted in our language. Recent neurobiological insights into this gut-brain crosstalk have revealed a complex, bidirectional communication system that not only ensures the proper maintenance of gastrointestinal homeostasis and digestion but is likely to have multiple effects on affect, motivation and higher cognitive functions, including intuitive decision making. Moreover, disturbances of this system have been implicated in a wide range of disorders, including functional and inflammatory gastrointestinal disorders, obesity and eating disorders.

引用

页码：453 / 466

页数：14

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