Replication of loci influencing ages at menarche and menopause in Hispanic women: the Womens Health Initiative SHARe Study

被引：64

作者：

Chen, Christina T. L. ^{[1
]}

Fernandez-Rhodes, Lindsay ^{[2
]}

Brzyski, Robert G. ^{[4
]}

Carlson, Christopher S. ^{[1
]}

Chen, Zhao ^{[5
]}

Heiss, Gerardo ^{[2
]}

North, Kari E. ^{[2
,3
]}

Woods, Nancy F. ^{[6
]}

Rajkovic, Aleksandar ^{[7
]}

Kooperberg, Charles ^{[1
]}

Franceschini, Nora ^{[2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[2] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27514 USA

[3] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27514 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA

[5] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Epidemiol & Biostat, Tucson, AZ 85724 USA

[6] Univ Washington, Biobehav Nursing & Hlth Syst, Seattle, WA 98109 USA

[7] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA

来源：

HUMAN MOLECULAR GENETICS | 2012年 / 21卷 / 06期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; PREMATURE OVARIAN FAILURE; SEQUENCE VARIANTS; NATURAL MENOPAUSE; SMOKING; HEART; DETERMINANTS; METAANALYSIS; MORTALITY; MUTATION;

D O I：

10.1093/hmg/ddr570

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several genome-wide studies have identified loci associated with reproductive traits, such as ages of menarche and menopause, in women of European ancestry. In this study, we investigated the relevance of these loci in minority US Hispanic women. We utilized data from 3468 women who were genotyped as a part of the Womens Health Initiative SNP Health Association Resource. We replicated associations of eight loci (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 and OLFM2) with age at menarche, and of two loci (MCM8 and BRSK1/TMEM150B) with age at menopause. The MCM8 locus was also associated with early menopause risk. Three loci (CENPW, MCM8 and BRSK1/TMEM150B) were associated with the length of reproductive lifespan. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in minority US Hispanic women.

引用

页码：1419 / 1432

页数：14

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