Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice

被引:189
作者
Fatemi, SH
Emamian, ES
Kist, D
Sidwell, RW
Nakajima, K
Akhter, P
Shier, A
Sheikh, S
Bailey, K
机构
[1] Univ Minnesota, Sch Med, Div Neurosci Res, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Sch Med, Dept Cell Biol & Neuroanat, Minneapolis, MN 55455 USA
[4] Utah State Univ, Inst Antiviral Res, Logan, UT 84322 USA
[5] Jikei Univ, Sch Med, Inst DNA Med, Dept Mol Neurobiol,Minato Ku, Tokyo 1058461, Japan
关键词
prenatal; influenza; infection; Reelin; schizophrenia; mice;
D O I
10.1038/sj.mp.4000520
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent reports indicate an association between second trimester human influenza viral infection and later development of schizophrenia. Postmortem human brain studies also provide evidence for reduction in Reelin mRNA (an important secretory protein responsible for normal lamination of the brain) in schizophrenic brains. We hypothesized that human influenza infection in day 9 pregnant mice would alter the expression of reelin in day 0 neonatal brains. Prenatally-infected murine brains from postnatal day 0 showed significant reductions in reelin-positive cell counts in layer I of neocortex and other cortical and hippocampal layers when compared to controls. Whereas layer I Cajal-Retzius cells produced significantly less Reelin in infected animals, the same cells showed normal production of calretinin and nNOS when compared to control brains. Moreover, prenatal viral infection caused decreases in neocortical and hippocampal thickness. These results implicate a potential role of prenatal viral infection in causation of neuronal migration abnormalities via reduction in Reelin production in neonatal brains.
引用
收藏
页码:145 / 154
页数:10
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