The role of nanobiotechnology in drug discovery

被引:127
作者
Jain, KK [1 ]
机构
[1] Jain PharmaBiotech, CH-4057 Basel, Switzerland
关键词
D O I
10.1016/S1359-6446(05)03573-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The application of nanotechnology in life sciences, nanobiotechnology, is already having an impact on diagnostics and drug delivery. Now, researchers are starting to use nanotechnology in the field of drug discovery. This review explains how several technologies, including nanoparticles and nanodevices such as nanobiosensors and nanobiochips, are used to improve drug discovery and development. Nanoscale assays can contribute significantly to cost-saving in screening campaigns. In addition, some nanosubstances (such as fullerenes) could be potential drugs for the future. Although there might be some safety concerns with respect to the in vivo use of nanoparticles, studies are in place to determine the nature and extent of adverse events. Future prospects for the application of nanotechnology in healthcare and for the development of personalized medicine appear to be excellent.
引用
收藏
页码:1435 / 1442
页数:8
相关论文
共 30 条
[1]   A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties [J].
Ali, SS ;
Hardt, JI ;
Quick, KL ;
Kim-Han, JS ;
Erlanger, BF ;
Huang, TT ;
Epstein, CJ ;
Dugan, LL .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (08) :1191-1202
[2]   Biomolecular force measurements and the atomic force microscope [J].
Allison, DP ;
Hinterdorfer, P ;
Han, WH .
CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :47-51
[3]   Rapid functionalization of cantilever array sensors by inkjet printing [J].
Bietsch, A ;
Zhang, JY ;
Hegner, M ;
Lang, HP ;
Gerber, C .
NANOTECHNOLOGY, 2004, 15 (08) :873-880
[4]   Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors [J].
Chen, RJ ;
Bangsaruntip, S ;
Drouvalakis, KA ;
Kam, NWS ;
Shim, M ;
Li, YM ;
Kim, W ;
Utz, PJ ;
Dai, HJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :4984-4989
[5]   Targeting cancer cells with DNA-Assembled dendrimers - A mix and match strategy for cancer [J].
Choi, Y ;
Baker, JR .
CELL CYCLE, 2005, 4 (05) :669-671
[6]   Optical biosensors in drug discovery [J].
Cooper, MA .
NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (07) :515-528
[7]   Principles of nanoflow liquid chromatography and applications to proteomics [J].
Cutillas, PR .
CURRENT NANOSCIENCE, 2005, 1 (01) :65-71
[8]   Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking [J].
Dahan, M ;
Lévi, S ;
Luccardini, C ;
Rostaing, P ;
Riveau, B ;
Triller, A .
SCIENCE, 2003, 302 (5644) :442-445
[9]   Localization of single avidin-biotin interactions using simultaneous topography and molecular recognition imaging [J].
Ebner, A ;
Kienberger, F ;
Kada, G ;
Stroh, CM ;
Geretschläger, M ;
Kamruzzahan, ASM ;
Wildling, L ;
Johnson, WT ;
Ashcroft, B ;
Nelson, J ;
Lindsay, SM ;
Gruber, HJ ;
Hinterdorfer, P .
CHEMPHYSCHEM, 2005, 6 (05) :897-900
[10]  
Englebienne P, 2003, COMB CHEM HIGH T SCR, V6, P777