When Wnts antagonize Wnts

被引：75

作者：

Weidinger, G

Moon, RT

机构：

[1] Univ Washington, Dept Pharmacol, Sch Med, Seattle, WA 98195 USA

[2] Univ Washington, Sch Med, Howard Hughes Med Inst, Seattle, WA 98195 USA

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 162卷 / 05期

关键词：

D O I：

10.1083/jcb.200307181

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that "noncanonical" Wnt signaling inhibits the "canonical" Wnt/beta-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of beta-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/beta-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner.

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收藏

页码：753 / 755

页数：3

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