MicroRNA Functions in Stress Responses

被引：704

作者：

Leung, Anthony K. L. ^{[1
]}

Sharp, Phillip A. ^{[1
,2
]}

机构：

[1] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

MOLECULAR CELL | 2010年 / 40卷 / 02期

基金：

美国国家卫生研究院;

关键词：

RNA-BINDING PROTEIN; MESSENGER-RNAS; HUMAN-CELLS; CAENORHABDITIS-ELEGANS; SIGNAL-TRANSDUCTION; GENE-EXPRESSION; HUMAN CANCERS; TARGET SITES; P-BODIES; LOCALIZATION;

D O I：

10.1016/j.molcel.2010.09.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are a class of 22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding to stresses, cells either choose to restore or reprogram their gene expression patterns. This decision is partly mediated by miRNA functions, in particular by modulating the amount of miRNAs, the amount of mRNA targets, or the activity/mode of action of miRNA-protein complexes. In turn, these changes determine the specificity, timing, and concentration of gene products expressed upon stresses. Dysregulation of these processes contributes to chronic diseases, including cancers.

引用

页码：205 / 215

页数：11

共 86 条

[61] Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction [J].

Luo, Ji ;

Solimini, Nicole L. ;

Elledge, Stephen J. .

CELL, 2009, 136 (05) :823-837

[62] Most Caenorhabditis elegans microRNAs are individually not essential for development or viability [J].

Miska, Eric A. ;

Alvarez-Saavedra, Ezequiel ;

Abbott, Allison L. ;

Lau, Nelson C. ;

Hellman, Andrew B. ;

McGonagle, Shannon M. ;

Bartel, David P. ;

Ambros, Victor R. ;

Horvitz, H. Robert .

PLOS GENETICS, 2007, 3 (12) :2395-2403

[63] Diverse and specific gene expression responses to stresses in cultured human cells [J].

Murray, JI ;

Whitfield, ML ;

Trinklein, ND ;

Myers, RM ;

Brown, PO ;

Botstein, D .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (05) :2361-2374

[64] Heterogeneity in mammalian RNA 3′ end formation [J].

Neilson, Joel R. ;

Sandberg, Rickard .

EXPERIMENTAL CELL RESEARCH, 2010, 316 (08) :1357-1364

[65] MicroRNA-155 is induced during the macrophage inflammatory response [J].

O'Connell, Ryan M. ;

Taganov, Konstantin D. ;

Boldin, Mark P. ;

Cheng, Genhong ;

Baltimore, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (05) :1604-1609

[66] Physiological and pathological roles for microRNAs in the immune system [J].

O'Connell, Ryan M. ;

Rao, Dinesh S. ;

Chaudhuri, Aadel A. ;

Baltimore, David .

NATURE REVIEWS IMMUNOLOGY, 2010, 10 (02) :111-122

[67] Hsp90 Regulates the Function of Argonaute 2 and Its Recruitment to Stress Granules and P-Bodies [J].

Pare, Justin M. ;

Tahbaz, Nasser ;

Lopez-Orozco, Joaquin ;

LaPointe, Paul ;

Lasko, Paul ;

Hobman, Tom C. .

MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (14) :3273-3284

[68] Prolyl 4-hydroxylation regulates Argonaute 2 stability [J].

Qi, Hank H. ;

Ongusaha, Pat P. ;

Myllyharju, Johanna ;

Cheng, Dongmei ;

Pakkanen, Outi ;

Shi, Yujiang ;

Lee, Sam W. ;

Peng, Junmin ;

Shi, Yang .

NATURE, 2008, 455 (7211) :421-U78

[69] Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences [J].

Raj, Arjun ;

van Oudenaarden, Alexander .

CELL, 2008, 135 (02) :216-226

[70] The Heat Shock Response: Life on the Verge of Death [J].

Richter, Klaus ;

Haslbeck, Martin ;

Buchner, Johannes .

MOLECULAR CELL, 2010, 40 (02) :253-266

← 1 2 3 4 5 6 7 8 9 →