Epidemiology and Clinical Peculiarities of Norovirus and Rotavirus Infection in Hospitalized Young Children with Acute Diarrhea in Taiwan, 2009

被引:31
作者
Yang, Shu-Yan [2 ]
Hwang, Kao-Pin [1 ,2 ]
Wu, Fang-Tzy [3 ]
Wu, Ho-Sheng [3 ]
Hsiung, Chao Agnes [3 ]
Chang, Wan-Chi
Lin, Jen-Shiou [4 ,5 ]
Yang, Shun-Cheng [4 ,5 ]
Huang, Sun-Lin [6 ]
Huang, Yhu-Chering [6 ]
机构
[1] China Med Univ, China Med Univ Hosp, Div Pediat Infect Dis, Sch Med, Taichung 40447, Taiwan
[2] Chang Gung Univ, Coll Med, Div Pediat Infect Dis, Dept Pediat,Chang Gung Mem Hosp,Kaohsiung Med Ctr, Kaohsiung, Taiwan
[3] Ctr Dis Control, Dept Hlth, Taipei, Taiwan
[4] Changhua Christian Hosp, Div Pediat Infect Dis, Changhua, Taiwan
[5] Changhua Christian Hosp, Dept Lab Med, Changhua, Taiwan
[6] Chang Gung Univ, Coll Med, Div Pediat Infect Dis, Chang Gung Childrens Hosp, Tao Yuan, Taiwan
关键词
acute diarrhea; norovirus; rotavirus; Taiwan; young children; NORWALK-LIKE VIRUSES; MOLECULAR EPIDEMIOLOGY; ACUTE GASTROENTERITIS; SURVEILLANCE NETWORK; ECONOMIC BURDEN; PREVALENCE; SEASONALITY; SHANGHAI; FEATURES; WEATHER;
D O I
10.1016/S1684-1182(10)60078-3
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
BACKGROUND/PURPOSE: Acute diarrhea is one of the most common morbidities in pediatrics worldwide. We conducted a study to investigate the incidence of norovirus in young children hospitalized with acute diarrhea in Taiwan and its clinical peculiarity compared with rotavirus gastroenteritis. METHODS: Between January and December, 2009, patients younger than 5 years and admitted to hospital with acute diarrhea were randomly selected; and their stool samples were collected and tested for presence of rotavirus and norovirus by enzyme immunoassay and reverse transcription-polymerase chain reaction, respectively. The clinical manifestations and laboratory findings of the enrolled patients were analyzed. RESULTS: A total of 989 cases were enrolled with a mean age of 21.6 +/- 13.7 months and a male proportion of 56.0%. Rotavirus and norovirus was detected in 20.2% and 14.6% of all patients, respectively. Genogroup II was the predominant strain of norovirus (80.6%). Children aged 6-36 months accounted for the majority of patients positive for rotavirus and norovirus (73.0% and 81.3%, respectively). The incidences of norovirus and rotavirus infection were higher during winter and early spring. Most patients with rotavirus and norovirus diarrhea experienced vomiting (74.9% vs. 74.8%, respectively) and fever (94.7% vs. 71.3%, respectively). CONCLUSION: Most young diarrheal patients presenting with vomiting were likely to have norovirus or rotavirus infection. Patients with norovirus diarrhea experienced an absence of; or low-grade fever and longer duration of vomiting compared with those positive for rotavirus infection. A family history of current gastroenteritis may suggest the possibility of norovirus infection.
引用
收藏
页码:506 / 514
页数:9
相关论文
共 33 条
[1]
Temperature-dependent transmission of rotavirus in Great Britain and The Netherlands [J].
Atchison, C. J. ;
Tam, C. C. ;
Hajat, S. ;
van Pelt, W. ;
Cowden, J. M. ;
Lopman, B. A. .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2010, 277 (1683) :933-942
[2]
ROTAVIRUS GASTROENTERITIS AND WEATHER [J].
BRANDT, CD ;
KIM, HW ;
RODRIGUEZ, WJ ;
ARROBIO, JO ;
JEFFRIES, BC ;
PARROTT, RH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1982, 16 (03) :478-482
[3]
First report from the Asian rotavirus surveillance network [J].
Bresee, J ;
Fang, ZY ;
Wang, B ;
Nelson, EAS ;
Tam, J ;
Soenarto, Y ;
Wilopo, SA ;
Kilgore, P ;
Kim, JS ;
Kang, JO ;
Lan, WS ;
Gaik, CL ;
Moe, K ;
Chen, KT ;
Jiraphongsa, C ;
Pongsuwanna, Y ;
Van Man, N ;
Van Tu, P ;
Luan, LT ;
Hummelman, E ;
Gentsch, JR ;
Glass, R .
EMERGING INFECTIOUS DISEASES, 2004, 10 (06) :988-995
[4]
Chang CW, 2009, J MICROBIOL IMMUNOL, V42, P265
[5]
Hospital-based study of the economic burden associated with rotavirus diarrhea in Taiwan [J].
Chen, Kow-Tong ;
Fan, Shiang-Fang ;
Tang, Ren-Bin ;
Huang, Yung-Feng ;
Lee, Ping-Ing ;
Chen, Po-Yen ;
Tang, Chia-Wan ;
Chen, Hui-Chen .
VACCINE, 2007, 25 (21) :4266-4272
[6]
Microbial etiology of acute gastroenteritis in hospitalized children in Taiwan [J].
Chen, Shan-Ming ;
Ni, Yen-Hsuan ;
Chen, Huey-Ling ;
Chang, Mei-Hwei .
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2006, 105 (12) :964-970
[7]
Molecular epidemiology and clinical manifestations of viral gastroenteritis in hospitalized pediatric patients in northern Taiwan [J].
Chen, Shih-Yen ;
Chang, Yu-Chung ;
Lee, Yun-Shien ;
Chao, Hsun-Chin ;
Tsao, Kuo-Chien ;
Lin, Tzou-Yien ;
Ko, Tzu-Yin ;
Tsai, Chi-Neu ;
Chiu, Cheng-Hsun .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (06) :2054-2057
[8]
Infectious diarrhea in developed and developing countries [J].
Cheng, AC ;
McDonald, JR ;
Thielman, NM .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 2005, 39 (09) :757-773
[9]
Chiu T F, 2000, J Microbiol Immunol Infect, V33, P181
[10]
Prevalence and Clinical Characteristics of Norovirus Gastroenteritis Among Hospitalized Children in Spain [J].
Gutierrez Junquera, Carolina ;
Sainz de Baranda, Caridad ;
Garcia Mialdea, Olga ;
Balmaseda Serrano, Elena ;
Sanchez-Fauquier, Alicia .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2009, 28 (07) :604-607