Anti-angiogenic effects of the water extract of HangAmDan (WEHAD), a Korean traditional medicine

被引：15

作者：

Bang, Ji-Young ^{[1
]}

Kim, Kyung-Soon ^{[4
]}

Kim, Eung-Yoon ^{[1
]}

Yoo, Hwa-Seung ^{[4
]}

Lee, Yeon-Weol ^{[4
]}

Cho, Chong-Kwan ^{[4
]}

Choi, YoungJin ^{[3
]}

Jeong, Hyun-Ja ^{[3
]}

Kang, In-Cheol ^{[1
,2
,3
]}

机构：

[1] Hoseo Univ, InnoPharmasceen Inc, Asan 336795, South Korea

[2] Hoseo Univ, Coll Nat Sci, Dept Biol Sci, Asan 336795, South Korea

[3] Hoseo Univ, BioChip Res Ctr, Asan 336795, South Korea

[4] Daejeon Univ, EW Canc Ctr, Dunsan Oriental Med Hosp, Taejon 302122, South Korea

来源：

SCIENCE CHINA-LIFE SCIENCES | 2011年 / 54卷 / 03期

关键词：

angiogenesis; HangAmDan; WEHAD; antibody array; HUVEC; HUMAN ENDOTHELIAL-CELLS; IN-VIVO; APOPTOSIS; PEPTIDE; TRANSCRIPTION; ANTAGONISTS; PROTEOCHIP; ACTIVATION; VITRO; P73;

D O I：

10.1007/s11427-011-4144-3

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

We investigated the anti-angiogenic effects of the water extract of HangAmDan (WEHAD), which is a crude extract of nine Korean medicinal substances of animal and plant origin. In human umbilical vein endothelial cells, WEHAD significantly inhibited bFGF-induced proliferation, adhesion, migration, and capillary tube formation. We used an antibody array to perform an analysis of signaling proteins, which showed up-regulated expression of various proteins including RAD51, RAD52, and p73, and down-regulated expression of pFAK. Blood vessel formation in a chick chorioallantoic membrane (CAM) treated with WEHAD was markedly reduced in length compared with a PBS-treated control group. These results suggest that inhibition of angiogenesis by WEHAD may be the mechanism of action for the anti-cancer effects of HAD.

引用

页码：248 / 254

页数：7

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