Anti-angiogenic effects of the water extract of HangAmDan (WEHAD), a Korean traditional medicine

被引:15
作者
Bang, Ji-Young [1 ]
Kim, Kyung-Soon [4 ]
Kim, Eung-Yoon [1 ]
Yoo, Hwa-Seung [4 ]
Lee, Yeon-Weol [4 ]
Cho, Chong-Kwan [4 ]
Choi, YoungJin [3 ]
Jeong, Hyun-Ja [3 ]
Kang, In-Cheol [1 ,2 ,3 ]
机构
[1] Hoseo Univ, InnoPharmasceen Inc, Asan 336795, South Korea
[2] Hoseo Univ, Coll Nat Sci, Dept Biol Sci, Asan 336795, South Korea
[3] Hoseo Univ, BioChip Res Ctr, Asan 336795, South Korea
[4] Daejeon Univ, EW Canc Ctr, Dunsan Oriental Med Hosp, Taejon 302122, South Korea
关键词
angiogenesis; HangAmDan; WEHAD; antibody array; HUVEC; HUMAN ENDOTHELIAL-CELLS; IN-VIVO; APOPTOSIS; PEPTIDE; TRANSCRIPTION; ANTAGONISTS; PROTEOCHIP; ACTIVATION; VITRO; P73;
D O I
10.1007/s11427-011-4144-3
中图分类号
Q [生物科学];
学科分类号
090105 [作物生产系统与生态工程];
摘要
We investigated the anti-angiogenic effects of the water extract of HangAmDan (WEHAD), which is a crude extract of nine Korean medicinal substances of animal and plant origin. In human umbilical vein endothelial cells, WEHAD significantly inhibited bFGF-induced proliferation, adhesion, migration, and capillary tube formation. We used an antibody array to perform an analysis of signaling proteins, which showed up-regulated expression of various proteins including RAD51, RAD52, and p73, and down-regulated expression of pFAK. Blood vessel formation in a chick chorioallantoic membrane (CAM) treated with WEHAD was markedly reduced in length compared with a PBS-treated control group. These results suggest that inhibition of angiogenesis by WEHAD may be the mechanism of action for the anti-cancer effects of HAD.
引用
收藏
页码:248 / 254
页数:7
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