Genetic contribution of the tumor necrosis factor region in Guillain-Barre syndrome

被引：26

作者：

Ma, JJ

Nishimura, M ^{[1
]}

Mine, H

Kuroki, S

Nukina, M

Ohta, M

Saji, H

Obayashi, H

Kawakami, H

Saida, T

Uchiyama, T

机构：

[1] Natl Utano Hosp, Dept Neurol, Ukyo Ku, Kyoto 616, Japan

[2] Natl Utano Hosp, Clin Res Ctr, Ukyo Ku, Kyoto 616, Japan

[3] Kyoto Red Cross, Ctr Blood, Kyoto, Japan

[4] Kyoto Microbiol Inst, Kyoto, Japan

[5] Kyoto Univ, Inst Virus Res, Kyoto 606, Japan

[6] Kobe City Gen Hosp, Dept Pediat, Kobe, Hyogo, Japan

[7] Publ Hlth Res Inst, Kobe, Hyogo, Japan

[8] Hiroshima Univ, Sch Med, Dept Internal Med 1, Hiroshima 730, Japan

来源：

ANNALS OF NEUROLOGY | 1998年 / 44卷 / 05期

关键词：

D O I：

10.1002/ana.410440517

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain-Barre syndrome (GBS) and 85 controls. A significantly higher frequency of the 100-base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNF alpha production, existed in Campylobacter jejuni-positive (C-j(+)) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNF alpha secretion in the development of C. jejuni-related GBS.

引用

页码：815 / 818

页数：4

共 17 条

[1]

Asbury AK, 1990, ANN NEUROL S, V27, P21

[2]

Gruen JR, 1997, BLOOD, V90, P4252

[3]

Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis [J].