Kigamicins, novel antitumor antibiotics - I. Taxonomy, isolation, physico-chemical properties and biological activities

被引：48

作者：

Kunimoto, S

Lu, J

Esumi, H

Yamazaki, Y

Kinoshita, N

Honma, Y

Hamada, M

Ohsono, M

Ishizuka, M

Takeuchi, T

机构：

[1] Numazu Biomed Res Inst, Microbial Chem Res Ctr, Shizuoka 4100301, Japan

[2] Natl Canc Inst, Res Inst E, Chiba 2778577, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 12期

关键词：

D O I：

10.7164/antibiotics.56.1004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Novel antibiotics named kigamicin A, B, C, D, and E were discovered from the culture broth of Amycolatopsis sp. ML630-mF1 by their selective killing activity against PANC-1 cells only under a nutrient starved condition. Under a condition of nutrient starvation, kigamicins A, B, C, and D inhibited PANC-1 cell survival at 100 times lower concentration than in normal culture. Kigamicins showed antimicrobial activity against Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). Kigamicin D inhibited the growth of various mouse tumor cell lines at IC50 of about I mug/ml.

引用

页码：1004 / 1011

页数：8

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