Kigamicins, novel antitumor antibiotics - II. Structure determination

被引：38

作者：

Kunimoto, S

Someno, T

Yamazaki, Y

Lu, J

Esumi, H

Naganawa, H

机构：

[1] Numazu Biomed Res Inst, Microbial Chem Res Ctr, Shizuoka 4100301, Japan

[2] Natl Canc Ctr, Res Inst E, Chiba 2778577, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 12期

关键词：

D O I：

10.7164/antibiotics.56.1012

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.

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页码：1012 / 1017

页数：6

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