Sch 54445: A new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.

被引：30

作者：

Chu, M

Truumees, I

Mierzwa, R

Terracciano, J

Patel, M

Loebenberg, D

Kaminski, JJ

Das, P

Puar, MS

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07003

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 05期

关键词：

D O I：

10.1021/np960737v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel antifungal agent, Sch 54445, was isolated from the fermentation broth of an Actinoplanes species. Sch 54445 was identified as a polycyclic xanthone related to the albofungin family of compounds on the basis of analyses of spectroscopic data. As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values similar to 0.000 38 mu g/mL.

引用

页码：525 / 528

页数：4

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